The Development and Management of the Catastrophic Antiphospholipid Syndrome

The catastrophic antiphospholipid syndrome or CAPS is characterized by multiple organ bankruptcy. The mortality rate for this form of antiphospholipid syndrome is about fifty. Patients with systemic lupus erythematosus are prone to this condition. It might also arise in other rheumatic diseases such as systemic sclerosis, Sjogren syndrome and rheumatoid arthritis. The disorder stems from coagulation and will thus lead to blood clots or thrombosis. This process happens in both veins and arteries. Clotting systems will fail due to the catastrophic antiphospholipid syndrome. Therefore blood flow to vital organs will be limited. That is why the mortality rate is very high.

Dealing with catastrophic antiphospholipid syndrome in clinical terms

The condition becomes catastrophic after a progression from the milder form of antiphospholipid syndrome. Arterial blockage will then lead to further complications in the body. Some of these might include blood platelet output failures and miscarriage. There has been a registry that specifically collects information about the catastrophic antiphospholipid syndrome in order to help clinicians and patients when handling the condition. The trigger in about 50% of the cases is due to an infection, medication and injury. Likewise an operation can lead to the escalation of the condition. Cytokines will be activates due to a tempest and that will eventually lead to organ bankruptcy.  Catastrophic antiphospholipid syndrome can affect any part of the body at any time. However the kidneys have been identified as a particularly vulnerable part of the body. The patient will arrive at the emergency center with severe kidney problems.

The symptoms include reduced or no urine. They will also have a much higher blood force than is seen in healthy individuals. Mind roles will deteriorate and the patient may fall into a coma. In about a quarter of cases there will be strained respiration as well as non productive coughing. Patients will have left ventricular bankruptcy as well as blockages around the eyes. These blockages are accelerated due to hypertension as well as cerebral hemorrhaging. The treatment program for antiphospholipid syndrome includes anticoagulation drugs and steroids.  In some cases Plasmapheresis as well as intravenous immunoglobulin has been utilized in order to control some of the symptoms. The amount of plasma is reduced in order to improve blood circulation.

The blood is put under a process of centrifugation so that the plasma can be replaced with a saline solution. At that point fresh frozen plasma as well as other liquids will be returned to the patient in a solution. If the patient has been suffering from recurring miscarriage then they might be advised to take aspirin.  Aspirin is reputed to “thin” the blood. In some cases intravenous immunoglobulin may be used in the process of treating the patient. There are selected cases where cyclophosphamide is used to treat the condition. The most important thing is to preserve the life of the patient.  The development of antiphospholipid syndrome might be a chronic condition where it becomes important to monitor the patient for any early signs. That will ensure that there is less likelihood of fatalities.

Everything you need to Know about Ankylosing spondylitis

Although the name sounds slightly complicated, ankylosing spondylitis is a lot more common than the public thinks. It begins in the sacroiliac joints which are located at the back of the pelvis. The condition will then move up the spine to affect other parts of the body including the lumbar spine or lower back. It is one of the rheumatic diseases that have caused plenty of challenges for the medical world. It is much more common in white males than other similar groups. In fact clinical trials indicate that white male people are four times more likely to suffer from the condition than women. It is possible to combat the development of the condition through regular exercise. In particular patients should attempt to use different motions in order to keep the area active. Ankylosing spondylitis is sometimes a chronic condition where the patient simply has to learn ways of dealing with it instead of hoping for a permanent cure.

The proper management of ankylosing spondylitis

Patients with ankylosing spondylitis might find that they suffer from Iritis or eye inflammation. The appropriate treatment would involve an intervention to deal with the condition in all its forms right from the beginning. It is rare to perform surgery for patients unless there is a specific reason for such conditions. On the other hand the patient might benefit from the introduction of NSAIDs in order to keep the pain under control. The genetic market HLA B27 has been closely associated with this condition. It plays a role in the development of symptoms and might be the underlying factor when deciding on the most appropriate treatment program. Likewise heredity will be one of the ways in which this condition might develop. The first appearance of ankylosing spondylitis will be at the age of fifteen or thereabouts. However the condition can come in as late as forty five years of age.

There have been some famous faces with ankylosing spondylitis. The list of celebrities includes Pope John Paul II and Ed Sullivan. The treatment of ankylosing spondylitis will follow many of the guidelines that are provided for arthritis. In particular there will be focus on the pain management side of the treatment. Often patients with this condition will experience bouts of pain that can significantly reduce the quality of life that they lead. In order to overcome this problem it is often advisable to use NSAIDs.

It is not advisable to go for steroids because they have other side effects that might also reduce the quality of life for the patient. Surgery might be recommended if the patient is suffering from serious deformities as a consequence of a weakened bone structure. This is a serious decision that has to be taken on a holistic basis. The temporary relief from pain might not be matched by the long term implications of invasive surgery. The treatment program will be based on the broad principles of keeping the patient in a good position. Likewise there will be instances where the patient receives ongoing care.